Simple sequence length polymorphism is used as a genetic marker with polymerase chain reaction (PCR) . An SSLP is a type of polymorphism : a difference in the DNA sequence between individuals . The intergenic regions of SSLP deoxyribonucleic acid (DNA) are repeated sequences at different base lengths. Variation in SSLP length can be used to understand the genetic variation between two individuals in a certain species .
Application
An example of the use of SSLPs ( microsatellites ) is seen in a study by Rosenberg et al., where SSLP was used to cluster different continental castes . The study was pivotal to Nicholas Wade ‘s New York Times bestseller, Before the Dawn: Recovering the Lost History of Our Ancestors .
Rosenberg study
Rosenberg studied 377 SSLPs in 1000 people in 52 different regions of the world. Using PCR and cluster analysis , Rosenberg was able to group individuals who had similar SSLPs. These were extremely useful for the simple sequence length polymorphism experiment because they do not affect the phenotype of individuals, thus being unaffected by natural selection .
What do you understand by polymorphism?
In materials science, polymorphism is the ability of a solid substance to have more than one form or crystal structure. For example, coal, graphite and diamond are all three forms of carbon. Similarly both calcite and aragonite are polyforms of calcium carbonate.
2 What do you understand by DNA polymorphism?
In simple words, if (at high frequency) an underlying mutation is observed in a population, it is called a DNA polymorphism. Such variation seen in a noncoding DNA sequence would likely be high because mutations in these sequences may not have an immediate effect/impact in an individual’s fertility.
What do you understand by polymorphism, write its various properties?
In computer science, polymorphism is a feature of a programming language that helps to handle different types of data using a common interface. The concept of parametric polymorphism applies to both data types and functions.
What is a DNA tester, explain its utility in biotechnology?
Question: What is a DNA tester? State its utility in biotechnology. Genetic testing is an important health care tool that can tell people a lot about their bodies. These tests analyze a sample of a person’s DNA and look for specific changes associated with various conditions.
